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Activation of the atrial K(ACh) channel by the βγ subunits of G proteins or intracellular Na(+) ions depends on the presence of phosphatidylinositol phosphates

The βγ subunits of GTP-binding proteins (G(βγ)) activate the muscarinic K(+) channel (K(ACh)) in heart by direct binding to both of its component subunits. K(ACh) channels can also be gated by internal Na(+) ions. Both activation mechanisms show dependence on hydrolysis of intracellular ATP. We repo...

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Bibliografiske detaljer
Main Authors: Sui, Jin Liang, Petit-Jacques, Jérôme, Logothetis, Diomedes E.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18753/
https://ncbi.nlm.nih.gov/pubmed/9448327
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