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Activation of the atrial K(ACh) channel by the βγ subunits of G proteins or intracellular Na(+) ions depends on the presence of phosphatidylinositol phosphates
The βγ subunits of GTP-binding proteins (G(βγ)) activate the muscarinic K(+) channel (K(ACh)) in heart by direct binding to both of its component subunits. K(ACh) channels can also be gated by internal Na(+) ions. Both activation mechanisms show dependence on hydrolysis of intracellular ATP. We repo...
Shranjeno v:
| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
1998
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18753/ https://ncbi.nlm.nih.gov/pubmed/9448327 |
| Oznake: |
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