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Activation of the atrial K(ACh) channel by the βγ subunits of G proteins or intracellular Na(+) ions depends on the presence of phosphatidylinositol phosphates
The βγ subunits of GTP-binding proteins (G(βγ)) activate the muscarinic K(+) channel (K(ACh)) in heart by direct binding to both of its component subunits. K(ACh) channels can also be gated by internal Na(+) ions. Both activation mechanisms show dependence on hydrolysis of intracellular ATP. We repo...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
1998
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18753/ https://ncbi.nlm.nih.gov/pubmed/9448327 |
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