ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR

p27(Kip1) restrains cell proliferation by binding to and inhibiting cyclin-dependent kinases. To investigate the mechanisms of p27 translational regulation, we isolated a complete p27 cDNA and identified an internal ribosomal entry site (IRES) located in its 5′UTR. The IRES allows for efficient p27...

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Pubblicato in:	Genes Dev
Autori principali:	Kullmann, Michael, Göpfert, Ulrich, Siewe, Basile, Hengst, Ludger
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2002
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187493/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12464637/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.248902
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