Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

A large number of human cancers display alterations in the Ink4a/cyclin D/Cdk4 genetic pathway, suggesting that activation of Cdk4 plays an important role in oncogenesis. Here we report that Cdk4-null mouse embryonic fibroblasts are resistant to transformation in response to Ras activation with domi...

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Bibliografiske detaljer
Main Authors: Zou, Xianghong, Ray, Dipankar, Aziyu, Aileen, Christov, Konstantin, Boiko, Alexander D., Gudkov, Andrei V., Kiyokawa, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2002
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC187486/
https://ncbi.nlm.nih.gov/pubmed/12435633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1033002
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