Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

A large number of human cancers display alterations in the Ink4a/cyclin D/Cdk4 genetic pathway, suggesting that activation of Cdk4 plays an important role in oncogenesis. Here we report that Cdk4-null mouse embryonic fibroblasts are resistant to transformation in response to Ras activation with domi...

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Publicat a:	Genes Dev
Autors principals:	Zou, Xianghong, Ray, Dipankar, Aziyu, Aileen, Christov, Konstantin, Boiko, Alexander D., Gudkov, Andrei V., Kiyokawa, Hiroaki
Format:	Artigo
Idioma:	Inglês
Publicat:	Cold Spring Harbor Laboratory Press 2002
Matèries:	Research Paper
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187486/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12435633/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1033002
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