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A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy
The 8;21 chromosomal translocation occurs in 15% to 40% of patients with the FAB M2 subtype of acute myeloid leukemia (AML). This chromosomal abnormality fuses part of the AML1/RUNX1 gene to the ETO/MTG8 gene and generates the AML1-ETO protein. We previously identified a C-terminal truncated AML1-ET...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1874577/ https://ncbi.nlm.nih.gov/pubmed/17197431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-045583 |
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