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Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus
How eukaryotes specify their replication origins is an important unanswered question. Here, we analyze the replicative organization of yeast rDNA, which consists of ∼150 identical repeats, each containing a potential origin. Using DNA combing and single-molecule imaging, we show that functional rDNA...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187456/ https://ncbi.nlm.nih.gov/pubmed/12368258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.232902 |
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