Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function
Sister-chromatid separation in mitosis requires proteolytic cleavage of a cohesin subunit. Separase, the corresponding protease, is activated at the metaphase-to-anaphase transition. Activation involves proteolysis of an inhibitory subunit, securin, following ubiquitination mediated by the anaphase-...
Uloženo v:
| Vydáno v: | Genes Dev |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187444/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12231632/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.242202 |
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