Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function

Sister-chromatid separation in mitosis requires proteolytic cleavage of a cohesin subunit. Separase, the corresponding protease, is activated at the metaphase-to-anaphase transition. Activation involves proteolysis of an inhibitory subunit, securin, following ubiquitination mediated by the anaphase-...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Herzig, Alf, Lehner, Christian F., Heidmann, Stefan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2002
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187444/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12231632/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.242202
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