The unbound percentage of saquinavir and indinavir remains constant throughout the dosing interval in HIV positive subjects

AIMS: To measure the unbound plasma concentrations of saquinavir (SQV) and indinavir (IDV) and to relate them to the total plasma concentrations in order to establish the unbound percentage of protease inhibitors in vivo during a full dosage interval profile. METHODS: HIV-infected subjects (n = 35;...

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Detalhes bibliográficos
Main Authors: Boffito, Marta, Hoggard, Patrick G, Reynolds, Helen E, Bonora, Stefano, Meaden, E Rhiannon, Sinicco, Alessandro, Perri, Giovanni Di, Back, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874417/
https://ncbi.nlm.nih.gov/pubmed/12236846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01663.x
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