Differential protein binding of indinavir and saquinavir in matched maternal and umbilical cord plasma

AIMS: To determine whether lower umbilical cord than maternal binding of indinavir and saquinavir contributed to the low cord : maternal (C : M) total concentration ratios reported previously. METHODS: Indinavir and saquinavir unbound fraction (fu) was determined using equilibrium dialysis. Buffer s...

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Autori principali: Sudhakaran, Sreeja, Rayner, Craig R, Li, Jian, Kong, David C M, Gude, Neil M, Nation, Roger L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2007
Soggetti:
Paediatric Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000742/
https://ncbi.nlm.nih.gov/pubmed/16981898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02766.x
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