An indirect response model of homocysteine suppression by betaine: optimising the dosage regimen of betaine in homocystinuria

AIMS: To investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of betaine in the treatment of classical homocystinuria due to cystathionine β-synthase (CβS) deficiency with a view to optimizing the dosage regimen. METHODS: Betaine was given as a single oral dose of 100 mg kg(−1) to six pat...

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Detalhes bibliográficos
Main Authors: Matthews, Angela, Johnson, Trevor N, Rostami-Hodjegan, Amin, Chakrapani, Anupam, Wraith, J Edward, Moat, Stuart J, Bonham, James R, Tucker, Geoffrey T
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874404/
https://ncbi.nlm.nih.gov/pubmed/12207633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01620.x
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