Omeprazole hydroxylation is inhibited by a single dose of moclobemide in homozygotic EM genotype for CYP2C19

AIMS: The pharmacokinetics of omeprazole and its metabolites in healthy subjects were evaluated to determine if a single dose of moclobemide inhibited CYP2C19 activity. METHODS: Sixteen volunteers, of whom eight were extensive metabolizers (EM) and eight were poor metabolizers for CYP2C19, participa...

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Bibliografiska uppgifter
Huvudupphovsmän: Cho, Joo-Youn, Yu, Kyung-Sang, Jang, In-Jin, Yang, Byung-Hwan, Shin, Sang-Goo, Yim, Dong-Seok
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2002
Ämnen:
Short Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874278/
https://ncbi.nlm.nih.gov/pubmed/11966672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01366.x
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