Pharmacokinetics and metabolism of oral midazolam in preterm infants

AIMS: To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm infants. METHODS: After an oral dose (0.1 mg kg(−1)), blood was drawn up to 24 h after administration. Midazolam and 1-OH-midazolam concentrations were determined with GC-MS. In 8 out of these 15 patients the p...

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Bibliographic Details
Main Authors: de Wildt, S N, Kearns, G L, Hop, W C J, Murry, D J, Abdel-Rahman, S M, van den Anker, J N
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2002
Subjects:
Short Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874268/
https://ncbi.nlm.nih.gov/pubmed/11966671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01223.x
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