Pharmacokinetic-pharmacodynamic model relating zabiciprilat plasma concentrations to brachial and femoral haemodynamic effects in normotensive volunteers

AIMS: To investigate, in healthy volunteers, the relationships between the plasma concentrations (C, ng ml(−1) ) of zabiciprilat, the active metabolite of the angiotensin I-converting enzyme inhibitor (ACEI) zabicipril, and the effects (E) induced on plasma converting enzyme activity (PCEA, nmol ml(...

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Bibliographic Details
Main Authors: Bellissant, Eric, Giudicelli, Jean-François
Format: Artigo
Language:Inglês
Published: Blackwell Science Ltd 1998
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874156/
https://ncbi.nlm.nih.gov/pubmed/9803988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.00786.x
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