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Sorivudine and 5-fluorouracil; a clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase
Sorivudine (1-β-d-arabinofuranosyl-E-5-[2-bromovinyl] uracil; BV-araU; SQ32,756) is an antimetabolite which is a synthetic analogue of thymidine. This drug has demonstrated antiviral activity against varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus. Clinical studies in Jap...
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| Format: | Artigo |
| Jezik: | Inglês |
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Blackwell Science Inc
1998
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1873978/ https://ncbi.nlm.nih.gov/pubmed/9690942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.00050.x |
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