Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects

AIMS: Dihydropyrimidine dehydrogenase (DPD) catalyses the reduction of pyrimidines, including the anticancer agent 5-fluorouracil (5FU). Impaired 5FU degradation, through low DPD activity, has led to severe, life-threatening or fatal toxicity after administration of 5FU. Complete DPD deficiency is a...

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Autori principali: Ridge, Susan A, Sludden, Julieann, Brown, Oliver, Robertson, Leigh, Wei, Xiaoxiong, Sapone, Andrea, Fernandez-Salguero, Pedro M, Gonzalez, Frank J, Vreken, Peter, van Kuilenburg, Andre BP, van Gennip, Albert H, McLeod, Howard L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 1998
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1873668/
https://ncbi.nlm.nih.gov/pubmed/9723824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.00751.x
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