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Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

AIMS: Chemical inhibitors of cytochrome P450 (CYP) are a useful tool in defining the role of individual CYPs involved in drug metabolism. The aim of the present study was to evaluate the selectivity and rank the order of potency of a range of isoform-selective CYP inhibitors and to compare directly...

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Main Authors: Eagling, Victoria A, Tjia, John F, Back, David J
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 1998
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1873357/
https://ncbi.nlm.nih.gov/pubmed/9491822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.00679.x
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