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Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme: RTOG protocol BR-0021
Preclinical studies support the concept that inhibition of protein kinase C (PKC) by tamoxifen (TAM) should provide both antineoplastic effects and radiosensitization. High-dose TAM (80 mg/m(2) p.o. daily in divided doses) was given with and after conventional radiotherapy (XRT) to inhibit PKC-media...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Duke University Press
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1871929/ https://ncbi.nlm.nih.gov/pubmed/16443947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/S1522851705000311 |
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