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Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo
U87MG human glioma cells in cultures expressed metabotropic glutamate (mGlu) receptors mGlu2 and mGlu3. Addition of the mGlu2/3 receptor antagonist LY341495 to the cultures reduced cell growth, expression of cyclin D1/2, and activation of the MAP kinase and phosphatidylinositol-3-kinase pathways. Th...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Duke University Press
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1871912/ https://ncbi.nlm.nih.gov/pubmed/16053698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/S1152851704000961 |
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