Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo

U87MG human glioma cells in cultures expressed metabotropic glutamate (mGlu) receptors mGlu2 and mGlu3. Addition of the mGlu2/3 receptor antagonist LY341495 to the cultures reduced cell growth, expression of cyclin D1/2, and activation of the MAP kinase and phosphatidylinositol-3-kinase pathways. Th...

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Detalhes bibliográficos
Main Authors: Arcella, Antonietta, Carpinelli, Giulia, Battaglia, Giuseppe, D’Onofrio, Mara, Santoro, Filippo, Ngomba, Richard Teke, Bruno, Valeria, Casolini, Paola, Giangaspero, Felice, Nicoletti, Ferdinando
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2005
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871912/
https://ncbi.nlm.nih.gov/pubmed/16053698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/S1152851704000961
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