Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes

HPV-16 E6 and E7 genes are required to efficiently immortalize a broad spectrum of cell types including cervical keratinocytes. Therefore, the E6/E7 genes can be considered relevant targets for anti-cancer therapy. We produced several engineered hairpin (HP) ribozymes to specifically disrupt HPV-16...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Alvarez-Salas, Luis M., Cullinan, Amy E., Siwkowski, Andrew, Hampel, Arnold, DiPaolo, Joseph A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448307/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1189
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