A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

Modifier screens have been powerful genetic tools to define signaling pathways in lower organisms. The identification of modifier loci in mice has begun to allow a similar dissection of mammalian signaling pathways. Transgenic mice (Btk(lo)) expressing 25% of endogenous levels of Bruton's tyros...

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Detalhes bibliográficos
Main Authors: Satterthwaite, Anne B., Willis, Fiona, Kanchanastit, Prim, Fruman, David, Cantley, Lewis C., Helgason, Cheryl D., Humphries, R. Keith, Lowell, Clifford A., Simon, Melvin, Leitges, Michael, Tarakhovsky, Alexander, Tedder, Thomas F., Lesche, Ralf, Wu, Hong, Witte, Owen N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18703/
https://ncbi.nlm.nih.gov/pubmed/10829070
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