Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death

Centromere protein C (CENPC) is a key protein that has been localized to the inner kinetochore plate of active mammalian centromeres. Using gene targeting techniques, we have disrupted the mouse Cenpc gene and shown that the gene is essential for normal mouse embryonic development. Heterozygous mice...

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Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Kalitsis, Paul, Fowler, Kerry J., Earle, Elizabeth, Hill, Joanne, Choo, K. H. Andy
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1998
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18698/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1136
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