Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death

Centromere protein C (CENPC) is a key protein that has been localized to the inner kinetochore plate of active mammalian centromeres. Using gene targeting techniques, we have disrupted the mouse Cenpc gene and shown that the gene is essential for normal mouse embryonic development. Heterozygous mice...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kalitsis, Paul, Fowler, Kerry J., Earle, Elizabeth, Hill, Joanne, Choo, K. H. Andy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18698/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1136
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