Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death

Centromere protein C (CENPC) is a key protein that has been localized to the inner kinetochore plate of active mammalian centromeres. Using gene targeting techniques, we have disrupted the mouse Cenpc gene and shown that the gene is essential for normal mouse embryonic development. Heterozygous mice...

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Detaylı Bibliyografya
Asıl Yazarlar: Kalitsis, Paul, Fowler, Kerry J., Earle, Elizabeth, Hill, Joanne, Choo, K. H. Andy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1998
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC18698/
https://ncbi.nlm.nih.gov/pubmed/9448298
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