Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas : A New Marker of DPC4 Inactivation

DPC4 (MADH4, SMAD4) is a tumor suppressor gene inactivated by allelic loss in approximately 55% of pancreatic adenocarcinomas. Unfortunately, it can be technically very difficult to detect the inactivation of DPC4 at the genetic level because genetic analyses require the microdissection of relativel...

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Hlavní autoři: Wilentz, Robb E., Su, Gloria H., Dai, Jia Le, Sparks, Andrew B., Argani, Pedram, Sohn, Taylor A., Yeo, Charles J., Kern, Scott E., Hruban, Ralph H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2000
Témata:
Short Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868651/
https://ncbi.nlm.nih.gov/pubmed/10623651
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