Nuclear Localization of Dpc4 (Madh4, Smad4) in Colorectal Carcinomas and Relation to Mismatch Repair/Transforming Growth Factor-β Receptor Defects

The tumor-suppressor protein Dpc4 (Smad4, Madh4) regulates gene expression. On binding of an extracellular ligand of the extensive transforming growth factor (TGF) superfamily to its cognate receptor complex, latent cytoplasmic Dpc4 is activated and translocated into the nucleus to function as part...

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Main Authors: Montgomery, Elizabeth, Goggins, Michael, Zhou, Shibin, Argani, Pedram, Wilentz, Robb E., Kaushal, Manju, Booker, Susan, Romans, Katharine, Bhargava, Parul, Hruban, Ralph H., Kern, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850322/
https://ncbi.nlm.nih.gov/pubmed/11159190
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