Nuclear Localization of Dpc4 (Madh4, Smad4) in Colorectal Carcinomas and Relation to Mismatch Repair/Transforming Growth Factor-β Receptor Defects

The tumor-suppressor protein Dpc4 (Smad4, Madh4) regulates gene expression. On binding of an extracellular ligand of the extensive transforming growth factor (TGF) superfamily to its cognate receptor complex, latent cytoplasmic Dpc4 is activated and translocated into the nucleus to function as part...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Montgomery, Elizabeth, Goggins, Michael, Zhou, Shibin, Argani, Pedram, Wilentz, Robb E., Kaushal, Manju, Booker, Susan, Romans, Katharine, Bhargava, Parul, Hruban, Ralph H., Kern, Scott E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2001
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850322/
https://ncbi.nlm.nih.gov/pubmed/11159190
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi