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Hepatocyte Cytokeratins Are Hyperphosphorylated at Multiple Sites in Human Alcoholic Hepatitis and in a Mallory Body Mouse Model

Alcoholic hepatitis (AH) is associated with cytokeratin 8 and 18 (CK8/18) accumulation as cytoplasmic inclusion bodies, termed Mallory bodies (MBs). Studies with MB mouse models and cultured hepatocytes suggested that CK8/18 hyperphosphorylation might be involved in MB formation. However, no data ex...

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Main Authors: Stumptner, Conny, Omary, M. Bishr, Fickert, Peter, Denk, Helmut, Zatloukal, Kurt
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Investigative Pathology 2000
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868635/
https://ncbi.nlm.nih.gov/pubmed/10623656
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