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T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes
The T cell receptor (TCR) can recognize a variety of cognate peptide/major histocompatibility complex (pMHC) ligands and translate their affinity into distinct cellular responses. To achieve this, the nonsignaling αβ heterodimer communicates ligand recognition to the CD3 signaling subunits by an unk...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868566/ https://ncbi.nlm.nih.gov/pubmed/15728235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042036 |
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