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Regulation of caspase-9 activity by differential binding to the apoptosome complex

Proteolytic processing of procaspase-9 is required for its activation, but processing in itself appears to be insufficient for its activity. We studied caspase activation in a cell-free system and found that incubation of cytosol from rat kidney proximal tubule cells with Cytochrome c (Cyt c) and dA...

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Main Authors: Saikumar, Pothana, Mikhailova, Margarita, Pandeswara, Sri Lakshmi
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868477/
https://ncbi.nlm.nih.gov/pubmed/17485304
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