Development of a Novel Therapeutic Suppressor of Brain Proinflammatory Cytokine Up-Regulation That Attenuates Synaptic Dysfunction and Behavioral Deficits

We report the development of a novel, aqueous-soluble, safe, small molecule, experimental therapeutic that suppresses injury-induced, proinflammatory cytokine increases in the brain, with resultant attenuation of synaptic protein biomarker loss and improvement in hippocampus-dependent behavioral def...

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Détails bibliographiques
Auteurs principaux: Hu, Wenhui, Ranaivo, Hantamalala Ralay, Roy, Saktimayee M., Behanna, Heather A., Wing, Laura K., Munoz, Lenka, Guo, Ling, Van Eldik, Linda J., Watterson, D. Martin
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868432/
https://ncbi.nlm.nih.gov/pubmed/17079143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.10.028
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