Synthesis of Polymer-supported Chiral Lithium Amide Bases and Application in Asymmetric Deprotonation of Prochiral Cyclic Ketones

Polymer-supported chiral amines were effectively prepared from amino acid derivatives and Merrifield resin. Treatment of polymer-supported amines with n-butyllithium gave the corresponding polymer-suppported chiral lithium amide bases, which were tested in the asymmetric deprotonation reactions of p...

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Bibliographic Details
Main Authors: Ma, Lili, Williard, Paul G.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868406/
https://ncbi.nlm.nih.gov/pubmed/18026563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetasy.2006.11.011
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