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Direct Asymmetric Amination of α-Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid

Here we report the direct asymmetric amination of α-substituted cyclic ketones catalyzed by a chiral phosphoric acid, yielding products with a N-containing quaternary stereocenter in high yields and excellent enantioselectivities. Kinetic resolution of the starting ketone was also found to occur on...

詳細記述

保存先:
書誌詳細
出版年:J Am Chem Soc
主要な著者: Yang, Xiaoyu, Toste, F. Dean
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562282/
https://ncbi.nlm.nih.gov/pubmed/25719604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00229
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