Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6(−/−) Mice

Transforming growth factor-β1 (TGF-β1) and the renin-angiotensin-aldosterone system are key mediators in kidney fibrosis. Integrin αvβ6, a heterodimeric matrix receptor expressed in epithelia, binds and activates latent TGF-β1. We used β6 integrin-null mice (β6(−/−)) to determine the role of local T...

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Bibliographic Details
Main Authors: Ma, Li-Jun, Yang, Haichun, Gaspert, Ariana, Carlesso, Gianluca, Barty, Melissa M., Davidson, Jeffrey M., Sheppard, Dean, Fogo, Agnes B.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868298/
https://ncbi.nlm.nih.gov/pubmed/14507636
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