Transforming Growth Factor-β1 Induces Smad3-Dependent β(1) Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis

Transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) contributes to the pathophysiological development of kidney fibrosis. Although it was reported that TGF-β1 enhances β(1) integrin levels in NMuMG cells, the detailed molecular mechanisms underlying TGF-β1-induc...

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Detalhes bibliográficos
Main Authors: Yeh, Yi-Chun, Wei, Wei-Chun, Wang, Yang-Kao, Lin, Shih-Chieh, Sung, Junne-Ming, Tang, Ming-Jer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947271/
https://ncbi.nlm.nih.gov/pubmed/20709799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091183
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