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Epithelial–Mesenchymal Interactions in Fibrosis and Repair. Transforming Growth Factor-β Activation by Epithelial Cells and Fibroblasts

Transforming growth factor-β (TGF-β) plays a central role in driving tissue fibrosis. TGF-β is secreted in a latent form, held latent by noncovalent association of the active cytokine with a peptide derived from cleavage of the N-terminal domain of the same gene product, and needs to be activated ex...

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Bibliografische gegevens
Gepubliceerd in:Ann Am Thorac Soc
Hoofdauteur: Sheppard, Dean
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Thoracic Society 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430968/
https://ncbi.nlm.nih.gov/pubmed/25830829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1513/AnnalsATS.201406-245MG
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