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Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy

The platelet-derived growth factors are implicated in development of fibrotic reactions and disease in several organs. We have overexpressed platelet-derived growth factor-C in the heart using the α-myosin heavy chain promoter and created a transgenic mouse that exhibits cardiac fibrosis followed by...

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Detalhes bibliográficos
Main Authors: Pontén, Annica, Li, Xuri, Thorén, Peter, Aase, Karin, Sjöblom, Tobias, Östman, Arne, Eriksson, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868211/
https://ncbi.nlm.nih.gov/pubmed/12875986
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