Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

ATM and PARP-1 are two of the most important players in the cell's response to DNA damage. PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers. Here we report that ATM and PARP-1 form a molecular complex in vivo in undamaged cells and...

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Main Authors: Aguilar-Quesada, Rocío, Muñoz-Gámez, José Antonio, Martín-Oliva, David, Peralta, Andreína, Valenzuela, Ma Teresa, Matínez-Romero, Rubén, Quiles-Pérez, Rosa, Murcia, Josiane Menissier-de, de Murcia, Gilbert, de Almodóvar, Mariano Ruiz, Oliver, F Javier
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868035/
https://ncbi.nlm.nih.gov/pubmed/17459151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-8-29
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