Microfluidic Deletion/Insertion Analysis for Rapid Screening of KIT and PDGFRA Mutations in CD117-Positive Gastrointestinal Stromal Tumors: Diagnostic Applications and Report of a New KIT Mutation

Gastrointestinal stromal tumors (GISTs) frequently harbor mutations in the KIT and PDGFRA genes, the presence and type of which correlate with the response to the kinase inhibitor imatinib mesylate. Because most GIST mutations are deletions/insertions, we used a microfluidic apparatus to detect thes...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zamò, Alberto, Bertolaso, Anna, Franceschetti, Ilaria, Weirich, Gregor, Capelli, Paola, Pecori, Sara, Chilosi, Marco, Hoefler, Heinz, Menestrina, Fabio, Scarpa, Aldo
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2007
Sujets:
Technical Advance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867442/
https://ncbi.nlm.nih.gov/pubmed/17384206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060041
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