Microfluidic Deletion/Insertion Analysis for Rapid Screening of KIT and PDGFRA Mutations in CD117-Positive Gastrointestinal Stromal Tumors: Diagnostic Applications and Report of a New KIT Mutation

Gastrointestinal stromal tumors (GISTs) frequently harbor mutations in the KIT and PDGFRA genes, the presence and type of which correlate with the response to the kinase inhibitor imatinib mesylate. Because most GIST mutations are deletions/insertions, we used a microfluidic apparatus to detect thes...

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Detalhes bibliográficos
Main Authors: Zamò, Alberto, Bertolaso, Anna, Franceschetti, Ilaria, Weirich, Gregor, Capelli, Paola, Pecori, Sara, Chilosi, Marco, Hoefler, Heinz, Menestrina, Fabio, Scarpa, Aldo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867442/
https://ncbi.nlm.nih.gov/pubmed/17384206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060041
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