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Reproductive Pathology and Sperm Physiology in Acid Sphingomyelinase-Deficient Mice

Types A and B Niemann-Pick disease (NPD) are lysosomal storage disorders resulting from the deficient activity of acid sphingomyelinase (ASM). In this manuscript we report the pathobiology of male gonadal tissue and sperm in a knockout mouse model of NPD and demonstrate the importance of ASM for nor...

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Autors principals: Butler, Avigdor, He, Xingxuan, Gordon, Ronald E., Wu, Hai-Shan, Gatt, Shimon, Schuchman, Edward H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867239/
https://ncbi.nlm.nih.gov/pubmed/12213735
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