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Heterogeneous Methylation and Deletion Patterns of the INK4a/ARF Locus Within Prostate Carcinomas

To elucidate the role of p53/p16(INK4a)/RB1 pathways in prostate carcinogenesis, we analyzed the p14(ARF), p16(INK4a), RB1, p21(Waf1), p27(Kip1), PTEN, p73, p53, and MDM2 gene status of multiple areas within 16 histologically heterogeneous prostate carcinomas using methylation-specific polymerase ch...

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Detalhes bibliográficos
Main Authors: Konishi, Noboru, Nakamura, Mitsutoshi, Kishi, Munehiro, Nishimine, Masayoshi, Ishida, Eiwa, Shimada, Keiji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867197/
https://ncbi.nlm.nih.gov/pubmed/11943705
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