Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast

Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden syndrome (CS), which is characterized by a high risk of breast and thyroid cancers. Loss of heterozygosity of 10q22–24 markers and somatic PTEN mutations have been found to a greater or lesser extent in a va...

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Main Authors: Perren, Aurel, Weng, Liang-Ping, Boag, Alexander H., Ziebold, Ulricke, Thakore, Kosha, Dahia, Patricia L. M., Komminoth, Paul, Lees, Jacqueline A., Mulligan, Lois M., Mutter, George L., Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 1999
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867038/
https://ncbi.nlm.nih.gov/pubmed/10514407
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