Mutation and Expression Analyses Reveal Differential Subcellular Compartmentalization of PTEN in Endocrine Pancreatic Tumors Compared to Normal Islet Cells

The pathogenesis of sporadic endocrine pancreatic tumors (EPTs) is still primarily unknown. Comparative genomic hybridization studies revealed loss of 10q in a significant number (nine of 31) of EPTs. The tumor suppressor gene PTEN lies on 10q23, and so, is a candidate to play some role in EPT patho...

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Detalhes bibliográficos
Main Authors: Perren, Aurel, Komminoth, Paul, Saremaslani, Parvin, Matter, Claudia, Feurer, Seraina, Lees, Jacqueline A., Heitz, Philipp U., Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2000
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850183/
https://ncbi.nlm.nih.gov/pubmed/11021813
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