Dysregulation of protein modification by ISG15 results in brain cell injury

UBP43 (USP18) is a protease that removes the ubiquitin-like modifier ISG15 from conjugated proteins. Here we present the first report of dysregulation of protein ISG15 modification by the generation of UBP43 knockout mice. In the absence of UBP43, brain tissue showed an elevated level of ISG15 conju...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ritchie, Kenneth J., Malakhov, Michael P., Hetherington, Christopher J., Zhou, Liming, Little, Marie-Terese, Malakhova, Oxana A., Sipe, Jack C., Orkin, Stuart H., Zhang, Dong-Er
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2002
Pynciau:
Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC186669/
https://ncbi.nlm.nih.gov/pubmed/12208842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1010202
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