Dysregulation of protein modification by ISG15 results in brain cell injury

UBP43 (USP18) is a protease that removes the ubiquitin-like modifier ISG15 from conjugated proteins. Here we present the first report of dysregulation of protein ISG15 modification by the generation of UBP43 knockout mice. In the absence of UBP43, brain tissue showed an elevated level of ISG15 conju...

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Detalhes bibliográficos
Main Authors: Ritchie, Kenneth J., Malakhov, Michael P., Hetherington, Christopher J., Zhou, Liming, Little, Marie-Terese, Malakhova, Oxana A., Sipe, Jack C., Orkin, Stuart H., Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC186669/
https://ncbi.nlm.nih.gov/pubmed/12208842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1010202
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