Endostatin Binds to Blood Vessels in Situ Independent of Heparan Sulfate and Does Not Compete for Fibroblast Growth Factor-2 Binding

Endostatin is a carboxyl-terminal proteolytic fragment of collagen XVIII and a potent inhibitor of angiogenesis. The mechanism of action is unknown, but the crystal structure of endostatin predicts a prominent heparan sulfate binding site, suggesting that endostatin competitively inhibits heparin-bi...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Chang, Zhen, Choon, Aung, Friedl, Andreas
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 1999
Ämnen:
Short Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866664/
https://ncbi.nlm.nih.gov/pubmed/10393839
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