Mature B cells class switched to IgD are autoreactive in healthy individuals

Determination of the origin and fate of autoreactive B cells is critical to understanding and treating autoimmune diseases. We report that, despite being derived from healthy people, antibodies from B cells that have class switched to IgD via genetic recombination (and thus become class switched to...

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Detalhes bibliográficos
Main Authors: Koelsch, Kristi, Zheng, Nai-Ying, Zhang, Qingzhao, Duty, Andrew, Helms, Christina, Mathias, Melissa D., Jared, Mathew, Smith, Kenneth, Capra, J. Donald, Wilson, Patrick C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866247/
https://ncbi.nlm.nih.gov/pubmed/17510706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27628
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