Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

In general, mammalian Ras guanine nucleotide exchange factors (RasGEFs) show little substrate specificity, although they are often thought to regulate specific pathways. Here, we provide in vitro and in vivo evidence that two RasGEFs can each act on specific Ras proteins. During Dictyostelium develo...

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Bibliografiske detaljer
Main Authors: Kae, Helmut, Kortholt, Arjan, Rehmann, Holger, Insall, Robert H, Van Haastert, Peter J M, Spiegelman, George B, Weeks, Gerald
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Scientific Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866193/
https://ncbi.nlm.nih.gov/pubmed/17380187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400936
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