Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

In general, mammalian Ras guanine nucleotide exchange factors (RasGEFs) show little substrate specificity, although they are often thought to regulate specific pathways. Here, we provide in vitro and in vivo evidence that two RasGEFs can each act on specific Ras proteins. During Dictyostelium develo...

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Main Authors: Kae, Helmut, Kortholt, Arjan, Rehmann, Holger, Insall, Robert H, Van Haastert, Peter J M, Spiegelman, George B, Weeks, Gerald
Formato: Artigo
Idioma:Inglês
Publicado: 2007
Assuntos:
Scientific Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866193/
https://ncbi.nlm.nih.gov/pubmed/17380187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400936
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